A retrospective case series: CAMPs for complex non‑healing wounds
DOI:
https://doi.org/10.63676/69fv4c62Keywords:
wound healing, pressure ulcer, negative pressure wound therapy, Cellular, acellular, and matrix-like products , quality of lifeAbstract
Background: Chronic non‑healing wounds impose substantial clinical and economic burdens on patients and society. Patients with multiple comorbidities and risk factors are particularly vulnerable to developing wounds with delayed healing. Advanced wound care therapy such as cellular, acellular, and matrix‑like products (CAMPs) support wound healing when conservative treatment is insufficient.
Results: Case 1 (91‑year‑old female, stage IV sacral ulcer): after wound‑bed preparation and 16 CAMP applications, surface area and volume reduced by 97% and 99%, respectively. Case 2 (74‑year‑old male, stage III sacral pressure ulcer while under treatment for pneumonia): 10 CAMP applications combined with negative pressure wound therapy (NPWT) achieved 70% surface area and 93% volume reduction; the patient subsequently died of pneumonia, unrelated to the wound. Case 3 (84‑year‑old female with dementia, venous leg ulcer with fat layer exposed): seven weekly CAMP applications with compression resulted in complete closure (100% reduction in area and volume). Case 4 (75-year-old female presented with an eight-year history of a chronic, non-pressure ulcer on the lower right leg with multiple ulcerations and sickle cell disease): 5 CAMP applications over 14 weeks achieving 100% healing. Case 5 (elderly male with pressure injury on lower right extremity: 10 CAMP applications with 100% wound healing.
Conclusions: This case series exemplifies how advanced therapies such as CAMP treatment, in combination with standard of care treatment and patient compliance, results in substantial wound improvement and closure. Timely access for patients to receive CAMP therapy is essential to improve healing outcomes and improve quality of life measures.
References
Sen CK. Human wound and its burden: updated 2022 compendium of estimates. Adv Wound Care (New Rochelle). 2023;12(12):657-670. https://doi.org/10.1089/wound.2023.0150 DOI: https://doi.org/10.1089/wound.2023.0150
Fife CE, Eckert KA, Carter MJ. Publicly reported wound healing rates: the fantasy and the reality. Adv Wound Care (New Rochelle). 2018;7(3):77-94. https://doi.org/10.1089/wound.2017.0743 DOI: https://doi.org/10.1089/wound.2017.0743
Wolny D, Štěpánek L, Horáková D, Thomas J, Zapletalová J, Patel MS. Risk factors for non-healing wounds-a single-centre study. J Clin Med. 2024;13(4):1003. https://doi.org/10.3390/jcm13041003 DOI: https://doi.org/10.3390/jcm13041003
Tettelbach WH, Driver V, Oropallo A, et al. Treatment patterns and outcomes of Medicare enrolees who developed venous leg ulcers. J Wound Care. 2023;32(11):704-718. https://doi.org/10.12968/jowc.2023.32.11.704 DOI: https://doi.org/10.12968/jowc.2023.32.11.704
Frykberg RG, Banks J. Challenges in the Treatment of Chronic Wounds. Adv Wound Care (New Rochelle). 2015;4(9):560-582. https://doi.org/10.1089/wound.2015.0635 DOI: https://doi.org/10.1089/wound.2015.0635
Zhang L, Weng T, Wu P, Li Q, Han C, Wang X. The combined use of negative-pressure wound therapy and dermal substitutes for tissue repair and regeneration. Biomed Res Int. 2020;2020:8824737. https://doi.org/10.1155/2020/8824737 DOI: https://doi.org/10.1155/2020/8824737
Crane MJ, Xu Y, Henry WL Jr, Gillis SP, Albina JE, Jamieson AM. Pulmonary influenza A virus infection leads to suppression of the innate immune response to dermal injury. PLoS Pathog. 2018;14(8):e1007212. https://doi.org/10.1371/journal.ppat.1007212 DOI: https://doi.org/10.1371/journal.ppat.1007212
Murray H, Duong R, Bain DS. Healing rate and time to closure of venous leg ulcers: a real-world service evaluation of neuromuscular electrostimulation as an adjunct to compression therapy. Adv Skin Wound Care. 2025;38(5):246-250. https://doi.org/10.1097/ASW.0000000000000299 DOI: https://doi.org/10.1097/ASW.0000000000000299
Sefcik JS, McLaurin EJ, Bass EJ, DiMaria-Ghalili RA. Chronic wounds in persons living with dementia: An integrative review. Int J Older People Nurs. 2022;17(3):e12447. https://doi.org/10.1111/opn.12447 DOI: https://doi.org/10.1111/opn.12447
Parker CN, Finlayson KJ, Edwards HE, MacAndrew M. Exploring the prevalence and management of wounds for people with dementia in long-term care. Int Wound J. 2020;17(3):650-659. https://doi.org/10.1111/iwj.13325 DOI: https://doi.org/10.1111/iwj.13325
LeBlanc K, Woo K, Gethin G, et al. Adults living with dementia and chronic wounds, wound types, care challenges, and impact across dementia stages: A scoping review protocol. J Tissue Viability. 2025;34(1):100845. https://doi.org/10.1016/j.jtv.2024.12.009 DOI: https://doi.org/10.1016/j.jtv.2024.12.009
Monfort JB, Senet P. Leg ulcers in sickle-cell disease: treatment update. Adv Wound Care (New Rochelle). 2020;9(6):348-356. https://doi.org/10.1089/wound.2018.0918 DOI: https://doi.org/10.1089/wound.2018.0918
Leigh R, Downie F. Wound healing in sickle cell leg ulcers. 2024. https://wounds-uk.com/journal-articles/wound-healing-in-sickle-cell-leg-ulcers/
Published
Data Availability Statement
Not publicly available data.
Issue
Section
License
Copyright (c) 2025 International Journal of Tissue Repair
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
